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Advances in newly developing therapy for chronic hepatitis C virus infection
Paul J. Pockros
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 166-174 doi: 10.1007/s11684-014-0334-2
Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and is often complicated by cirrhosis and hepatocellular carcinoma. Morbidity and mortality are decreased with the successful treatment of chronic HCV infection. Increased understanding of the HCV has allowed further development of new direct-acting antiviral (DAA) agents against the HCV and has also allowed the development of IFN-free oral treatment regimens. In late 2013 the first nucleotide polymerase inhibitor regimen with RBV alone for genotypes 2/3 and in combination with a 12-week regimen of PEG-IFN+RBV for genotypes 1, 4 was approved for use in the US. A number of promising new DAA regimens which are IFN-free are in phase 3 development and the first will likely be approved for use in the US in 2014. The currently approved regimens are discussed in detail and currently available data on future regimens are reviewed herein.
Keywords: direct-acting antiviral (DAA) nucleotide polymerase inhibitors protease inhibitors
Expression of protease-activated receptors on platelets in healthy individuals
Rui ZHU, Lin SHEN
Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 236-239 doi: 10.1007/s11684-009-0040-7
Keywords: protease-activated receptors platelet
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4, Pages 433-444 doi: 10.1007/s11705-014-1454-6
Keywords: Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular
Abbas TEIMOURI, Nasrin SOLTANI, Alireza Najafi CHERMAHINI
Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 1, Pages 43-50 doi: 10.1007/s11705-010-0532-7
Keywords: corrosion inhibitors mild steel acidic medium theoretical studies DFT
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 46-53 doi: 10.1007/s11684-010-0010-0
Keywords: mitogen-activated protein kinase drug target inhibitor signal transduction disease
Zhen Xiang, Yingyan Yu
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 24-31 doi: 10.1007/s11684-019-0679-7
Keywords: immune checkpoint blockade sensitivity resistance data mining
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 307-321 doi: 10.1007/s11684-022-0927-0
Keywords: tumor immunotherapy immune checkpoint inhibitor antibiotics gut microbiota drug–drug interaction
Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, Pages 133-145 doi: 10.15302/J-FASE-2021401
Keywords: herbicide / HPPD / inhibitor / quinoxaline / triketon
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 32-44 doi: 10.1007/s11684-018-0678-0
Keywords: immune checkpoint companion diagnosis PD-L1 tumor mutation burden immune score
Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 449-461 doi: 10.1007/s11684-017-0589-5
Keywords: emerging and re-emerging viruses small-molecule inhibitor coronavirus Ebola virus Zika virus life cycle
design of novel proton-pump inhibitors with reduced adverse effects
Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu
Frontiers of Medicine 2019, Volume 13, Issue 2, Pages 277-284 doi: 10.1007/s11684-018-0630-3
Keywords: proton-pump inhibitor adverse effect pharmacological mechanism toxicological mechanism pKa calculation
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 701-713 doi: 10.1007/s11684-022-0951-0
Keywords: acquired resistance EGFR inhibitor apoptosis lung cancer
Precision medicine in acute lymphoblastic leukemia
Ching-Hon Pui
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 689-700 doi: 10.1007/s11684-020-0759-8
Keywords: acute lymphoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 773-783 doi: 10.1007/s11684-021-0902-1
Keywords: benefit China eligibility immune checkpoint inhibitor public health
Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 18-42 doi: 10.1007/s11684-022-0976-4
Keywords: non-small cell lung cancer driver mutations treatment strategy resistant mechanism immune-checkpoint inhibitors
Title Author Date Type Operation
Advances in newly developing therapy for chronic hepatitis C virus infection
Paul J. Pockros
Journal Article
Expression of protease-activated receptors on platelets in healthy individuals
Rui ZHU, Lin SHEN
Journal Article
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
Journal Article
Synthesis of mono and bis-4-methylpiperidiniummethyl-urea as corrosion inhibitors for steel in acidic
Abbas TEIMOURI, Nasrin SOLTANI, Alireza Najafi CHERMAHINI
Journal Article
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
Journal Article
Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases
Zhen Xiang, Yingyan Yu
Journal Article
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy
Journal Article
DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESIGN
Journal Article
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian
Journal Article
Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging
Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang
Journal Article
design of novel proton-pump inhibitors with reduced adverse effects
Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu
Journal Article
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors
Journal Article
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors
Journal Article